The separate axes of TECPR1 and ATG16L1 in CASM

Namrita Kaur; Sven R Carlsson; Alf Håkon Lystad

doi:10.1080/15548627.2023.2255462

The separate axes of TECPR1 and ATG16L1 in CASM

Autophagy. 2024 Jan;20(1):214-215. doi: 10.1080/15548627.2023.2255462. Epub 2023 Sep 7.

Authors

Namrita Kaur^{1

2}, Sven R Carlsson³, Alf Håkon Lystad^{1

2}

Affiliations

¹ Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Oslo, Norway.
² Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
³ Department of Medical Biochemistry and Biophysics, University of Umeå, Sweden.

Abstract

Conjugation of ATG8 to single membranes (CASM) is a fundamental cellular process that entails the conjugation of mammalian Atg8 homologs, here referred to as ATG8, to phosphatidylethanolamine (PE) and phosphatidylserine (PS) on endolysosomal compartments. Our current research, together with recent reports from the Randow, Wu, and Wileman labs, has uncovered yet another layer to this process. We discovered that, in addition to ATG16L1-containing complexes, TECPR1 (tectonin beta-propeller repeat containing 1)-containing ATG12-ATG5 E3 complexes can facilitate CASM, thereby providing a broader understanding of this pathway.

Keywords: CASM; DysF; SopF; membrane damage; non-canonical autophagy; sphingomyelin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autophagy*
Autophagy-Related Protein 5 / metabolism
Autophagy-Related Proteins / metabolism
Mammals / metabolism
Microtubule-Associated Proteins* / metabolism

Substances

Autophagy-Related Proteins
Microtubule-Associated Proteins
Autophagy-Related Protein 5

Grants and funding

This work was partly supported by a Young Research Talents Grant from the Research Council of Norway (Project number 325305) and through its Centres of Excellence funding scheme (project number 262652).