Immune-mediated facial nerve paralysis in a myeloma patient post B-cell maturation antigen-targeted chimeric antigen receptor T cells

Yamini K Kathari; Haroon Ahmad; Michael E Kallen; Rima Koka; Destiny Omili; Thierry Iraguha; Jean Clement; Lily Pham; Mazhar Khalid; Xiaoxuan Fan; Etse Gebru; Patricia Lesho; Esther Park; Nishanthini Dishanthan; Jillian M Baker; Kenneth A Dietze; Kim G Hankey; Ashraf Badros; Jean A Yared; Saurabh Dahiya; Nancy M Hardy; Hakan Kocoglu; Tim Luetkens; Aaron P Rapoport; Djordje Atanackovic

doi:10.3324/haematol.2023.283296

Immune-mediated facial nerve paralysis in a myeloma patient post B-cell maturation antigen-targeted chimeric antigen receptor T cells

Haematologica. 2024 Feb 1;109(2):682-688. doi: 10.3324/haematol.2023.283296.

Authors

Yamini K Kathari¹, Haroon Ahmad², Michael E Kallen³, Rima Koka³, Destiny Omili⁴, Thierry Iraguha⁴, Jean Clement¹, Lily Pham², Mazhar Khalid², Xiaoxuan Fan⁵, Etse Gebru⁴, Patricia Lesho⁶, Esther Park⁶, Nishanthini Dishanthan⁴, Jillian M Baker⁷, Kenneth A Dietze⁷, Kim G Hankey¹, Ashraf Badros⁸, Jean A Yared⁸, Saurabh Dahiya⁹, Nancy M Hardy⁸, Hakan Kocoglu⁸, Tim Luetkens¹⁰, Aaron P Rapoport⁸, Djordje Atanackovic¹¹

Affiliations

¹ University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.
² University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD.
³ Department of Pathology, University of Maryland School of Medicine, Baltimore, MD.
⁴ University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Transplant and Cellular Therapy Program, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD.
⁵ University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Microbiology and Immunology, University of Maryland, Baltimore, MD.
⁶ University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD.
⁷ Department of Microbiology and Immunology, University of Maryland, Baltimore, MD.
⁸ University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Transplant and Cellular Therapy Program, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD.
⁹ University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Transplant and Cellular Therapy Program, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Stanford University, Stanford, CA.
¹⁰ University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Transplant and Cellular Therapy Program, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Microbiology and Immunology, University of Maryland, Baltimore, MD.
¹¹ University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Transplant and Cellular Therapy Program, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Microbiology and Immunology, University of Maryland, Baltimore, MD. datanackovic@som.umaryland.edu.

No abstract available

MeSH terms

B-Cell Maturation Antigen
Facial Nerve
Humans
Immunotherapy, Adoptive / adverse effects
Multiple Myeloma* / complications
Multiple Myeloma* / therapy
Paralysis
Receptors, Chimeric Antigen*
T-Lymphocytes

Substances

Receptors, Chimeric Antigen
B-Cell Maturation Antigen

Grants and funding

P30 CA134274/CA/NCI NIH HHS/United States