Minimizing blood loss in laparoscopic myomectomy with temporary occlusion of the hypogastric artery

Ligia Balulescu; Samuel Nistor; Diana Lungeanu; Simona Brasoveanu; Marilena Pirtea; Cristina Secosan; Dorin Grigoras; Radu Caprariu; Andrea Pasquini; Laurentiu Pirtea

doi:10.3389/fmed.2023.1216455

Minimizing blood loss in laparoscopic myomectomy with temporary occlusion of the hypogastric artery

Front Med (Lausanne). 2023 Aug 22:10:1216455. doi: 10.3389/fmed.2023.1216455. eCollection 2023.

Authors

Ligia Balulescu^{1

2}, Samuel Nistor^{3

4}, Diana Lungeanu^{3

5}, Simona Brasoveanu^{1

2}, Marilena Pirtea^{1

2}, Cristina Secosan^{1

2}, Dorin Grigoras^{1

2}, Radu Caprariu⁶, Andrea Pasquini^{3

7}, Laurentiu Pirtea^{1

2}

Affiliations

¹ Department of Obstetrics and Gynecology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
² Department of Obstetrics and Gynecology, Timisoara Municipal Emergency Clinical Hospital, Timisoara, Romania.
³ Center for Modeling Biological Systems and Data Analysis, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
⁴ Institute of Cardiovascular Diseases, Timisoara, Romania.
⁵ Department of Functional Sciences, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
⁶ Department of Radiology and Medical Imaging, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
⁷ "Pius Brinzeu" County Clinical Emergency Hospital, Timisoara, Romania.

Abstract

Introduction: Uterine leiomyomas are common benign pelvic tumors. Currently, laparoscopic myomectomy (LM) is the preferred treatment option for women in the fertile age group with symptomatic myomas. The authors hypothesize that combining LM with a bilateral temporary occlusion of the hypogastric artery (TOHA) using vascular clips minimizes uterine blood flow during surgery and can significantly reduce surgery-associated blood loss.

Materials and methods: This single-center, prospective randomized study was conducted at the Department of Obstetrics and Gynecology, Municipal Emergency Clinical Hospital Timisoara, Romania. Patients aged between 18 and 49 who preferred laparoscopic myomectomy and wished to preserve fertility were included, provided they had intramural uterine leiomyomas larger than 4 cm in diameter that deformed the uterine cavity. The study analyzed data from 60 laparoscopic myomectomies performed by a single surgeon between January 2018 and December 2020. Patients were randomly assigned to either: "LM + TOHA" group (29 patients), and "LM" group (31 patients). The study's main objective was to evaluate the impact of TOHA on perioperative blood loss, expressed as mean differences in Hb (delta Hb).

Results: Delta Hb was statistically lower in the "LM + TOHA" group compared to "LM" group, with mean ± standard (min-max): 1.68 ± 0.67 (0.39-3.99) vs. 2.63 ± 1.06 (0.83-4.92) g/dL, respectively (p < 0.001). There was a statistically significant higher need for postoperative iron perfusion in the "LM" group, specifically 0 vs. 12 patients (p < 0.001), and lower postoperative anemia in "LM + TOHA" group (p < 0.001). Necessary artery clipping time was 10.62 ± 2.47 (7-15) minutes, with no significant impact on overall operative time: 110.2 ± 13.65 vs. 106.3 ± 16.48 (p = 0.21). There was no difference in the length of hospitalization or 12-month post-intervention fertility.

Discussion: Performing bilateral TOHA prior to laparoscopic myomectomy has proven to be a valuable technique in reducing surgery-associated blood loss, while minimizing complications during surgery, with no significant increase in the overall operative time.

Clinical trial registration: ISRCTN registry, (www.isrctn.com), identifier ISRCTN66897343.

Keywords: blood loss; clipping; laparoscopic myomectomy; operative time; temporary occlusion of the hypogastric artery (TOHA); uterine leiomyoma; uterine myomectomy.