Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis

Jingyi Shan; Suxian Liu; Haoyue Liu; Jianye Yuan; Jiang Lin

doi:10.3389/fphar.2023.1221849

Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis

Front Pharmacol. 2023 Aug 22:14:1221849. doi: 10.3389/fphar.2023.1221849. eCollection 2023.

Authors

Jingyi Shan^#^{1

2}, Suxian Liu^#^{1

2}, Haoyue Liu³, Jianye Yuan^#², Jiang Lin^#¹

Affiliations

¹ Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
³ Department of Intensive Care Unit, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

^# Contributed equally.

Abstract

Ulcerative colitis (UC) is a refractory inflammatory bowel disease, and the outcomes of conventional therapies of UC, including 5-aminosalicylic acid, glucocorticoids, immunosuppressants, and biological agents, are not satisfied with patients and physicians with regard to adverse reactions and financial burden. The abnormality of the intestinal mucosal barrier in the pathogenesis of UC was verified. Qingchang Suppository (QCS) is an herbal preparation and is effective in treating ulcerative proctitis. The mechanism of QCS and its active ingredients have not been concluded especially in mucosal healing. This review elucidated the potential mechanism of QCS from the intestinal mucosal barrier perspective to help exploring future QCS research directions.

Keywords: Qingchang Suppository; active ingredients; intestinal mucosal barrier; mechanism; ulcerative colitis.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 82104743), the Shanghai Municipal Health Commission and Shanghai Municipal Administrator of Traditional Chinese Medicine (ZY(2021-2023)-0207-01) and Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Longhua Hospital Innovation Project (KY2056).