BRAF
V600E
promotes DC3/monocyte differentiation in human gene-engineered HSPCs and causes multisystem histiocytosis
Leukemia
.
2023 Nov;37(11):2292-2296.
doi: 10.1038/s41375-023-02019-3.
Epub 2023 Sep 6.
Authors
Tommaso Sconocchia
1
,
Johannes Foßelteder
1
,
Lisa Auinger
1
,
Erdem Özkaya
1
,
Theresa Benezeder
2
,
Magdalena Lang
3
,
Christine Beham-Schmid
4
,
Gerald Hoefler
4
,
Armin Zebisch
1
5
,
Albert Wölfler
1
,
Heinz Sill
1
,
Peter Wolf
2
,
Herbert Strobl
3
,
Andreas Reinisch
6
7
Affiliations
1
Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
2
Department of Dermatology, Medical University of Graz, Graz, Austria.
3
Division of Immunology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria.
4
Diagnostic & Research Institute of Pathology, Medical University of Graz, Graz, Austria.
5
Division of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology, and Inflammation, Medical University of Graz, Graz, Austria.
6
Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. a.reinisch@medunigraz.at.
7
Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria. a.reinisch@medunigraz.at.
PMID:
37673974
PMCID:
PMC10624620
DOI:
10.1038/s41375-023-02019-3
No abstract available
Publication types
Research Support, Non-U.S. Gov't
MeSH terms
Hematopoiesis
Histiocytosis*
Humans
Monocytes
Mutation
Proto-Oncogene Proteins B-raf* / genetics
Substances
Proto-Oncogene Proteins B-raf
BRAF protein, human
Grants and funding
P32783/Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung)
I5021/Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung)
Clinical Research Grant/Österreichische Gesellschaft für Hämatologie und Onkologie (Austrian Society for Haematology and Medical Oncology)