SIRPα: A key player in innate immunity

Yongyi Feng; Chunliu Huang; Yingzhao Wang; Jun Chen

doi:10.1002/eji.202350375

SIRPα: A key player in innate immunity

Eur J Immunol. 2023 Nov;53(11):e2350375. doi: 10.1002/eji.202350375. Epub 2023 Sep 17.

Authors

Yongyi Feng¹, Chunliu Huang², Yingzhao Wang³, Jun Chen^{1

4

5

6}

Affiliations

¹ Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
² Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
³ Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
⁴ Guangdong Engineering & Technology Research Center for Disease-Model Animals, Laboratory Animal Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
⁵ Key Laboratory of Tropical Disease Control of the Ministry of Education, Sun Yat-sen University, Guangzhou, China.
⁶ Jinfeng Laboratory, Chongqing, China.

PMID: 37672390
DOI: 10.1002/eji.202350375

Abstract

Signal regulatory protein alpha (SIRPα) is a crucial inhibitory regulator expressed on the surface of myeloid cells, including macrophages, dendritic cells, monocytes, neutrophils, and microglia. SIRPα plays an indispensable role in innate immune and adoptive immune responses in cancer immunology, tissue homeostasis, and other physiological or phycological conditions. This review provides an overview of the research history, ligands, signal transduction pathways, and functional mechanisms associated with SIRPα. Additionally, we summarize the therapeutic implications of targeting SIRPα as a promising novel strategy in immuno-oncology.

Keywords: CD47; Cancer immunology; Diseases; Innate immunity; SIRPα.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Differentiation
Humans
Immunity, Innate
Macrophages
Myeloid Cells / metabolism
Neoplasms*
Phagocytosis*

Substances

Antigens, Differentiation