Function and clinical application of exosome-how to improve tumor immunotherapy?

Siwen Qin; Jilong Cao; Xiaoxue Ma

doi:10.3389/fcell.2023.1228624

Function and clinical application of exosome-how to improve tumor immunotherapy?

Front Cell Dev Biol. 2023 Aug 21:11:1228624. doi: 10.3389/fcell.2023.1228624. eCollection 2023.

Authors

Siwen Qin¹, Jilong Cao², Xiaoxue Ma³

Affiliations

¹ Department of Pediatrics, The Fourth Hospital of China Medical University, Shenyang, China.
² Party Affairs and Administration Office, The Fourth Hospital of China Medical University, Shenyang, China.
³ Department of Pediatrics, The First Hospital of China Medical University, Shenyang, China.

Abstract

In recent years, immunotherapy has been increasingly used in clinical practice to treat tumors. However, immunotherapy's efficacy varies between tumor types and patient populations, and long-term drug resistance often occurs during treatment. Therefore, it is essential to explore the molecular mechanisms of immunotherapy to improve its efficacy. In this review, we focus on the significance of tumor-derived exosomes in the clinical treatment of tumors and how modifying these exosomes may enhance immune effectiveness. Specifically, we discuss exosome components, such as RNA, lipids, and proteins, and the role of membrane molecules on exosome surfaces. Additionally, we highlight the importance of engineered exosomes for tumor immunotherapy. Our goal is to propose new strategies to improve the efficacy of tumor immunotherapy.

Keywords: engineered exosomes; exosome contents; exosome membrane molecules; immunotherapy; tumor.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (grant 81901658); Liaoning Province Natural Science Foundation (2022-BS-134).