Pulmonary artery wedge pressure and left ventricular end-diastolic pressure during exercise in patients with dyspnoea

Claudia Baratto; Andrea Faini; Gianluca P Gallone; Céline Dewachter; Giovanni B Perego; Antoine Bondue; Denisa Muraru; Michele Senni; Luigi P Badano; Gianfranco Parati; Jean-Luc Vachiéry; Sergio Caravita

doi:10.1183/23120541.00750-2022

Pulmonary artery wedge pressure and left ventricular end-diastolic pressure during exercise in patients with dyspnoea

ERJ Open Res. 2023 Sep 4;9(4):00750-2022. doi: 10.1183/23120541.00750-2022. eCollection 2023 Jul.

Authors

Claudia Baratto¹, Andrea Faini^{1

2}, Gianluca P Gallone¹, Céline Dewachter³, Giovanni B Perego¹, Antoine Bondue³, Denisa Muraru^{1

4}, Michele Senni^{4

5}, Luigi P Badano^{1

4}, Gianfranco Parati^{1

4}, Jean-Luc Vachiéry³, Sergio Caravita^{1

6}

Affiliations

¹ Department of Cardiology, Istituto Auxologico Italiano IRCCS, Ospedale San Luca, Milan, Italy.
² Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.
³ Department of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme, Brussels, Belgium.
⁴ Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
⁵ Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
⁶ Department of Management, Information and Production Engineering, University of Bergamo, Dalmine, Italy.

Abstract

Background: Pulmonary artery wedge pressure (PAWP) during exercise, as a surrogate for left ventricular (LV) end-diastolic pressure (EDP), is used to diagnose heart failure with preserved ejection fraction (HFpEF). However, LVEDP is the gold standard to assess LV filling, end-diastolic PAWP (PAWP_ED) is supposed to coincide with LVEDP and mean PAWP throughout the cardiac cycle (PAWP_M) better reflects the haemodynamic load imposed on the pulmonary circulation. The objective of the present study was to determine precision and accuracy of PAWP estimates for LVEDP during exercise, as well as the rate of agreement between these measures.

Methods: 46 individuals underwent simultaneous right and left heart catheterisation, at rest and during exercise, to confirm/exclude HFpEF. We evaluated: linear regression between LVEDP and PAWP, Bland-Altman graphs, and the rate of concordance of dichotomised LVEDP and PAWP ≥ or < diagnostic thresholds for HFpEF.

Results: At peak exercise, PAWP_M and LVEDP, as well as PAWP_ED and LVEDP, were fairly correlated (R²>0.69, p<0.01), with minimal bias (+2 and 0 mmHg respectively) but large limits of agreement (±11 mmHg). 89% of individuals had concordant PAWP and LVEDP ≥ or <25 mmHg (Cohen's κ=0.64). Individuals with either LVEDP or PAWP_M ≥25 mmHg showed a PAWP_M increase relative to cardiac output (CO) changes (PAWP_M/CO slope) >2 mmHg·L^-1·min^-1.

Conclusions: During exercise, PAWP is accurate but not precise for the estimation of LVEDP. Despite a good rate of concordance, these two measures might occasionally disagree.