Unveiling abundance-dependent metabolic phenotypes of microbial communities

mSystems. 2023 Oct 26;8(5):e0049223. doi: 10.1128/msystems.00492-23. Epub 2023 Sep 5.

Abstract

In nature, organisms live in communities and not as isolated species, and their interactions provide a source of resilience to environmental disturbances. Despite their importance in ecology, human health, and industry, understanding how organisms interact in different environments remains an open question. In this work, we provide a novel approach that, only using genomic information, studies the metabolic phenotype exhibited by communities, where the exploration of suboptimal growth flux distributions and the composition of a community allows to unveil its capacity to respond to environmental changes, shedding light of the degrees of metabolic plasticity inherent to the community.

Keywords: constrained-based modeling; metabolic plasticity; microbial communities.

MeSH terms

  • Ecology
  • Genomics
  • Humans
  • Microbiota* / genetics