The (pro)renin receptor as a pharmacological target in cardiorenal diseaes

Heiko Funke-Kaiser; Thomas Unger

doi:10.1038/s41440-023-01424-6

The (pro)renin receptor as a pharmacological target in cardiorenal diseaes

Hypertens Res. 2023 Nov;46(11):2527-2534. doi: 10.1038/s41440-023-01424-6. Epub 2023 Sep 4.

Authors

Heiko Funke-Kaiser¹, Thomas Unger²

Affiliations

¹ CCR Pharma (CCRP) Therapeutics, Berlin, Germany. heiko@funke-kaiser.com.
² CARIM - School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.

PMID: 37667044
DOI: 10.1038/s41440-023-01424-6

Abstract

The (pro)renin receptor ((P)RR) is not only a member of the renin-angiotensin system (RAS) but also exerts several RAS-independent functions due to its multiple signal transductions pathways. In this mini-review, we shortly discuss the molecular functions of this receptor and its pathophysiological significance with a focus on cardiorenal diseases. Finally, we provide a short summary regarding a drug discovery and drug development program on small molecule-based renin/ prorenin receptor blockers (RERBs).

Keywords: (Pro)renin receptor (P)RR; Cardiorenal; Cardiovascular; Drug target; End-organ damage; Oncology.

Publication types

Review

MeSH terms

Prorenin Receptor*
Receptors, Cell Surface / metabolism
Renin / metabolism
Renin-Angiotensin System / physiology
Signal Transduction / physiology
Vacuolar Proton-Translocating ATPases* / metabolism

Substances

Prorenin Receptor
Renin
Receptors, Cell Surface
Vacuolar Proton-Translocating ATPases