Extracellular vesicle lipids in cancer immunoevasion

Siyu Chen; Dalila Iannotta; Megan L O'Mara; Jenifer Pendiuk Goncalves; Joy Wolfram

doi:10.1016/j.trecan.2023.08.006

Extracellular vesicle lipids in cancer immunoevasion

Trends Cancer. 2023 Nov;9(11):883-886. doi: 10.1016/j.trecan.2023.08.006. Epub 2023 Sep 4.

Authors

Siyu Chen¹, Dalila Iannotta², Megan L O'Mara³, Jenifer Pendiuk Goncalves⁴, Joy Wolfram⁵

Affiliations

¹ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Building 75, Cnr College Rd & Cooper Rd, Brisbane, QLD 4072, Australia.
² School of Chemical Engineering, The University of Queensland, Andrew N. Liveris Building, 46 Staff House Rd, Brisbane, QLD 4072, Australia.
³ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Building 75, Cnr College Rd & Cooper Rd, Brisbane, QLD 4072, Australia. Electronic address: m.omara@uq.edu.au.
⁴ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Building 75, Cnr College Rd & Cooper Rd, Brisbane, QLD 4072, Australia. Electronic address: j.pendiukgoncalves@uq.edu.au.
⁵ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Building 75, Cnr College Rd & Cooper Rd, Brisbane, QLD 4072, Australia; School of Chemical Engineering, The University of Queensland, Andrew N. Liveris Building, 46 Staff House Rd, Brisbane, QLD 4072, Australia; Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA. Electronic address: j.wolfram@uq.edu.au.

PMID: 37666676
DOI: 10.1016/j.trecan.2023.08.006

Abstract

Recent studies have revealed that cancer cell-derived extracellular vesicles (EVs) modulate immunological responses. Lipids have diverse biological functions, and are known to promote tumor malignancy. However, the immunoevasive roles of EV lipids in cancer progression remain poorly understood. Nevertheless, the study of cancer cell-derived EV lipids holds great promise for diagnostic and therapeutic interventions.

Keywords: exosome; immunosuppression; lipidomics; microvesicle; oncology.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Extracellular Vesicles* / pathology
Humans
Lipids
Neoplasms* / pathology

Substances

Lipids