Associations between intraindividual reaction time variability and prospective memory performance in patients with schizophrenia and healthy controls

Jia-Li Liu; Tao Chen; Ji-Fang Cui; Hai-Song Shi; Ming-Yuan Gan; Ya Wang

doi:10.1080/13546805.2023.2255344

Associations between intraindividual reaction time variability and prospective memory performance in patients with schizophrenia and healthy controls

Cogn Neuropsychiatry. 2023 Sep;28(5):333-341. doi: 10.1080/13546805.2023.2255344. Epub 2023 Sep 4.

Authors

Jia-Li Liu^{1

2}, Tao Chen^{1

2

3

4}, Ji-Fang Cui⁵, Hai-Song Shi⁶, Ming-Yuan Gan⁷, Ya Wang^{1

2}

Affiliations

¹ Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, People's Republic of China.
² Department of Psychology, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
³ Brain and Mind Centre, The University of Sydney, Sydney, Australia.
⁴ School of Psychology, The University of Sydney, Sydney, Australia.
⁵ Institute of Educational Information and Statistics, National Institute of Education Sciences, Beijing, People's Republic of China.
⁶ North China Electric Power University, Beijing, People's Republic of China.
⁷ Beijing Huilongguan Hospital, Beijing, People's Republic of China.

PMID: 37665566
DOI: 10.1080/13546805.2023.2255344

Abstract

Introduction: Patients with schizophrenia exhibit prospective memory (PM) impairment. Intraindividual reaction time variability (IIRTV) is an index of attentional control that is required for PM. This study examined the differences in IIRTV between patients with schizophrenia and healthy controls and the relationship between IIRTV and PM performance.Method: Thirty-nine patients with schizophrenia and forty-two healthy controls were recruited to complete a PM task and the Sustained Attention to Response Task. IIRTV was calculated as the coefficient of variation (mean/SD) of reaction time over correctly responded trials in these tasks.Results: Patients with schizophrenia showed lower PM accuracy and increased IIRTV, while the associations between PM accuracy and IIRTV were significant in healthy controls but not in patients with schizophrenia.Conclusion: These findings suggest impaired PM and relationship between PM and attentional control in patients with schizophrenia.

Keywords: Prospective memory; attentional control; intraindividual variability; reaction time; schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cognition
Humans
Memory Disorders
Memory, Episodic*
Reaction Time / physiology
Schizophrenia*