Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study

Jun Xie; Jinyun Wang; Rong Zeng; Yong Xie

doi:10.3389/fendo.2023.1220347

Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study

Front Endocrinol (Lausanne). 2023 Aug 16:14:1220347. doi: 10.3389/fendo.2023.1220347. eCollection 2023.

Authors

Jun Xie^{1

2

3}, Jinyun Wang^{1

2

3}, Rong Zeng^{1

2

3}, Yong Xie^{1

2

3}

Affiliations

¹ Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
² Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
³ Department of Gastroenterology, Jiangxi Clinical Research Center for Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Abstract

Background: Currently, the available evidence regarding the relationship between the lipid profile and Helicobacter pylori (H. pylori) infection is limited and conflicting. There is also a dearth of studies that have explored the possibility of sex-specific differences in the association between H. pylori infection and triglyceride levels.

Methods: We conducted a cross-sectional study involving 1,146 participants utilizing data from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 conducted in the United States. A logistic regression model was employed to evaluate the association between H. pylori seropositivity and triglyceride levels. Subgroup analyses stratified by sex were conducted to explore sex-specific differences in this association.

Results: Serum triglyceride levels were significantly higher in H. pylori-seropositive participants than in H. pylori-seronegative participants. In the logistic regression analysis, there was a positive correlation between H. pylori seropositivity and triglyceride levels (OR=1.231; 95% CI, 1.016-1.491; P=0.033). In the subgroup analysis, the adjusted association between serum triglycerides and H. pylori seropositivity was significant in females (OR=1.732; 95% CI, 1.113-2.696; P=0.015) but not in males (OR=1.091; 95% CI, 0.698-1.705; P=0.704).

Conclusion: The association between high triglyceride levels and H. pylori infection is specific to the female population.

Keywords: Helicobacter pylori infection; NHANES; cdc; females; triglycerides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cross-Sectional Studies
Female
Helicobacter Infections* / complications
Helicobacter Infections* / epidemiology
Helicobacter pylori*
Humans
Male
Nutrition Surveys
Triglycerides

Substances

Triglycerides

Grants and funding

This study was supported by the National Natural Science Foundation of China [No.81970502, No.81860107, No.82060109] and the Science and Technology Project of Jiangxi Province [No.20203BBG73051, No.20201ZDG02007].