Cross-regulation between SOX9 and the canonical Wnt signalling pathway in stem cells

Jiajia Wang; Xichen Wan; Qihua Le

doi:10.3389/fmolb.2023.1250530

Cross-regulation between SOX9 and the canonical Wnt signalling pathway in stem cells

Front Mol Biosci. 2023 Aug 17:10:1250530. doi: 10.3389/fmolb.2023.1250530. eCollection 2023.

Authors

Jiajia Wang¹, Xichen Wan¹, Qihua Le^{1

2

3}

Affiliations

¹ Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
² Research Center, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
³ Myopia Key Laboratory of Ministry of Health, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.

Abstract

SOX9, a member of the SRY-related HMG-box transcription factors, has been reported to critically regulate fetal development and stem cell homeostasis. Wnt signalling is a highly conserved signalling pathway that controls stem cell fate decision and stemness maintenance throughout embryonic development and adult life. Many studies have shown that the interactions between SOX9 and the canonical Wnt signalling pathway are involved in many of the physiological and pathological processes of stem cells, including organ development, the proliferation, differentiation and stemness maintenance of stem cells, and tumorigenesis. In this review, we summarize the already-known molecular mechanism of cross-interactions between SOX9 and the canonical Wnt signalling pathway, outline its regulatory effects on the maintenance of homeostasis in different types of stem cells, and explore its potential in translational stem cell therapy.

Keywords: SOX9 transcription factor; Wnt signalling pathway; crosstalk; signalling transduction; stem cell.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (81970767).