Rest-activity rhythm associated with depressive symptom severity and attention among patients with major depressive disorder: a 12-month follow-up study

Hang-Ju Yang; Wan-Ju Cheng; Mi-Chun Hsiao; Sheng-Che Huang; Tomohide Kubo; Liang-Wen Hang; Wei-Sheng Lee

doi:10.3389/fpsyt.2023.1214143

Rest-activity rhythm associated with depressive symptom severity and attention among patients with major depressive disorder: a 12-month follow-up study

Front Psychiatry. 2023 Aug 10:14:1214143. doi: 10.3389/fpsyt.2023.1214143. eCollection 2023.

Authors

Hang-Ju Yang¹, Wan-Ju Cheng^{2

3}, Mi-Chun Hsiao⁴, Sheng-Che Huang⁵, Tomohide Kubo⁶, Liang-Wen Hang^{7

8}, Wei-Sheng Lee⁴

Affiliations

¹ Department of Emergency Medicine, Jen Ai Hospital Dali Branch, Taichung, Taiwan.
² Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan.
³ National Center for Geriatrics and Welfare Research, National Health Research Institutes, Miaoli, Taiwan.
⁴ Center for Drug Abuse and Addiction, China Medical University Hospital, China Medical University, Taichung, Taiwan.
⁵ Department of Public Health, China Medical University, Taichung, Taiwan.
⁶ National Institute of Occupational Safety and Health, Kawasaki, Japan.
⁷ Department of Pulmonary and Critical Care Medicine, Sleep Medicine Center, China Medical University Hospital, Taichung, Taiwan.
⁸ School of Nursing and Graduate Institute of Nursing, China Medical University, Taichung, Taiwan.

Abstract

Introduction: Patients with depressive disorder demonstrate rest-activity rhythm disturbances and cognitive function impairment. This study examined the association of individual rest-activity rhythm changes over time with mood symptoms and attention.

Methods: We recruited 15 adult outpatients with a diagnosis of major depressive disorder from a single medical center and observed them for 12 months. Weekly rest-activity parameters, including rhythm characteristics generated from nonparametric circadian rhythm analysis, were retrieved from actigraphy data. Attention was evaluated weekly with a smartphone-based psychomotor vigilance test upon awakening. Depressive symptom severity was evaluated using the Beck Depression Inventory (BDI) fortnightly. The association of rest-activity parameters with BDI score and attention was examined using generalized linear mixed regression. A fixed-effects analysis was used to examine the association between rest-activity parameters and depressive episodes.

Results: An advanced bedtime and most active continuous 10 h starting time were associated with depressive symptom severity but also associated with higher vigilance test performance. A longer sleep duration, mainly due to an earlier bedtime, was associated with depressive symptom severity. Compared to remission, sleep duration was 27.8 min longer during depressive episodes, and bed time was 24 min earlier. A shorter sleep duration and increased activity during sleep were associated with poorer attention.

Discussion: Rest-activity rhythms change with mood symptoms among patients with depressive disorder. The circadian rhythms of rest-activity among patients with depressive disorder should be distinguished during various mood states in future studies.

Keywords: chronotype; cognition; mood disorder; rhythm; sleep.