Editorial: Acute-on-chronic liver failure: systemic inflammation and immunosuppression

Olaf Tyc; Yu Shi; Yu-Chen Fan; Jonel Trebicka; Xiaogang Xiang

doi:10.3389/fimmu.2023.1260749

Editorial: Acute-on-chronic liver failure: systemic inflammation and immunosuppression

Front Immunol. 2023 Aug 15:14:1260749. doi: 10.3389/fimmu.2023.1260749. eCollection 2023.

Authors

Olaf Tyc¹, Yu Shi², Yu-Chen Fan³, Jonel Trebicka^{4

5}, Xiaogang Xiang⁶

Affiliations

¹ Medical Clinic 1, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
² State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
³ Department of Hepatology, Qilu Hospital, Shandong University, Jinan, China.
⁴ Department of Internal Medicine B, University Hospital of Münster, Münster, Germany.
⁵ European Foundation for the Study of Chronic Liver Failure (EF-CLIF), Barcelona, Spain.
⁶ Department of Infectious Diseases, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

No abstract available

Keywords: acute-on-chronic liver failure; chronic liver disease; immunosuppression; pathophysiological mechanisms; systemic inflammation.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Acute-On-Chronic Liver Failure*
Humans
Immune Tolerance
Immunosuppression Therapy

Grants and funding

OT was supported by the research funding program Landes-Offensive zur Entwicklung Wissenschaftlich-ökonomischer Exzellenz (LOEWE) of the State of Hesse (HMWK), Research Initiative ACLF-I. JT was supported by the German Research Foundation (DFG) project ID 403224013 – SFB 1382 (A09), by the German Federal Ministry of Education and Research (BMBF) for the DEEP-HCC project, and by the Hessian Ministry of Higher Education, Research and the Arts (HMWK) for the ENABLE and ACLF-I cluster projects. The MICROB-PREDICT (project ID 825694), DECISION (project ID 847949), GALAXY (project ID 668031), LIVERHOPE (project ID 731875), and IHMCSA (project ID 964590) projects have received funding from the European Union’s Horizon 2020 research and innovation program. The manuscript reflects only the authors’ views, and the European Commission is not responsible for any use that may be made of the information it contains. The funders had no influence on the study design, data collection, and analysis, the decision to publish, or the preparation of the manuscript. This research received also funding from the Fundamental Research Funds for the Central Universities (2021FZZX001-41,226-2023-00127), Medical Health Science and Technology Project of Zhejiang Provincial Health Commission (No.2022490480), and Chinese National Natural Science Foundation (No.81870425).