Research on the biological mechanism and potential application of CEMIP

Front Immunol. 2023 Aug 18:14:1222425. doi: 10.3389/fimmu.2023.1222425. eCollection 2023.

Abstract

Cell migration-inducing protein (CEMIP), also known as KIAA1199 and hyaluronan-binding protein involved in hyaluronan depolymerization, is a new member of the hyaluronidase family that degrades hyaluronic acid (HA) and remodels the extracellular matrix. In recent years, some studies have reported that CEMIP can promote the proliferation, invasion, and adhesion of various tumor cells and can play an important role in bacterial infection and arthritis. This review focuses on the pathological mechanism of CEMIP in a variety of diseases and expounds the function of CEMIP from the aspects of inhibiting cell apoptosis, promoting HA degradation, inducing inflammatory responses and related phosphorylation, adjusting cellular microenvironment, and regulating tissue fibrosis. The diagnosis and treatment strategies targeting CEMIP are also summarized. The various functions of CEMIP show its great potential application value.

Keywords: CEMIP; HA; cell microenvironment; fibrosis; pro-inflammatory factor; tumor.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis
  • Arthritis*
  • Cell Movement
  • Humans
  • Hyaluronic Acid*
  • Hyaluronoglucosaminidase

Substances

  • Hyaluronic Acid
  • Hyaluronoglucosaminidase

Grants and funding

This work was supported by the National Natural Science Foundation of China (82072267, 82272271, 82172215, and 81871562), Science and Technology Project of Guangdong Province (2021A1515011396 and 2021A1515012109), and Shenzhen Futian District Public Health Research Project (FTWS2020017 and FTWS2020008).