Spatial and temporal mapping of neuron-microglia interaction modes in acute ischemic stroke

Xiaoke Dou; Wei Ji; Maosha Dai; Shujun Sun; Rui Chen; Juexi Yang; Junhao Long; Yangyang Ge; Yun Lin

doi:10.1016/j.bcp.2023.115772

Spatial and temporal mapping of neuron-microglia interaction modes in acute ischemic stroke

Biochem Pharmacol. 2023 Oct:216:115772. doi: 10.1016/j.bcp.2023.115772. Epub 2023 Sep 1.

Authors

Xiaoke Dou¹, Wei Ji², Maosha Dai¹, Shujun Sun³, Rui Chen¹, Juexi Yang¹, Junhao Long¹, Yangyang Ge⁴, Yun Lin⁵

Affiliations

¹ Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China.
² Department of Anesthesiology, Yantai Affiliated Hospital of BinZhou Medical College, Yantai 264000, China.
³ Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China; Department of Pain, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
⁴ Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China. Electronic address: geyangyang123@hust.edu.cn.
⁵ Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China. Electronic address: franklinyun@hust.edu.cn.

PMID: 37659736
DOI: 10.1016/j.bcp.2023.115772

Abstract

Ischemic stroke (IS) is a major cause of morbidity and mortality worldwide, accounting for 75-80% of all strokes. Under conditions of ischemia and hypoxia, neurons suffer damage or death, leading to a series of secondary immune reactions. Microglia, the earliest activated immune cells, can exert neurotoxic or neuroprotective effects on neurons through secretion of factors. There exists a complex interaction between neurons and microglia during this process. Moreover, the interaction between them becomes even more complex due to differences in the infarct area and reperfusion time. This review first elaborates on the differences in neuronal death modes between the ischemic core and penumbra, and then introduces the differences in microglial markers across different infarct areas with varying reperfusion time, indicating distinct functions. Finally, we focus on exploring the interaction modes between neurons and microglia in order to precisely target beneficial interactions and inhibit harmful ones, thus providing new therapeutic strategies for the treatment of IS.

Keywords: EVs; Interaction; Ischemic stroke; Microglia; Neuron.

Publication types

Review