RNA methylation, homologous recombination repair and therapeutic resistance

Yu Bai; Hanlin Zhao; Haijun Liu; Wei Wang; Hongming Dong; Chenghai Zhao

doi:10.1016/j.biopha.2023.115409

RNA methylation, homologous recombination repair and therapeutic resistance

Biomed Pharmacother. 2023 Oct:166:115409. doi: 10.1016/j.biopha.2023.115409. Epub 2023 Sep 4.

Authors

Yu Bai¹, Hanlin Zhao², Haijun Liu³, Wei Wang⁴, Hongming Dong⁵, Chenghai Zhao⁶

Affiliations

¹ Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China; Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.
² Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.
³ Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
⁴ Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China. Electronic address: wangwei07@cmu.edu.cn.
⁵ Department of Anatomy, College of Basic Medical Science, China Medical University, Shenyang, China. Electronic address: hmdong@cmu.edu.cn.
⁶ Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China. Electronic address: chzhao@cmu.edu.cn.

PMID: 37659205
DOI: 10.1016/j.biopha.2023.115409

Abstract

Homologous recombination (HR) repair of DNA double-strand breaks (DSBs) is critical for maintaining genomic integrity and stability. Defects in HR increase the risk of tumorigenesis. However, many human tumors exhibit enhanced HR repair capabilities, consequently endowing tumor cells with resistance to DNA-damaging chemotherapy and radiotherapy. This review summarizes the role of RNA methylation in HR repair and therapeutic resistance in human tumors. We also analyzed the interactions between RNA methylation and other HR-modulating modifications including histone acetylation, histone deacetylation, ubiquitination, deubiquitination, protein arginine methylation, and gene transcription. This review proposes that targeting RNA methylation is a promising approach to overcoming HR-mediated therapeutic resistance.

Keywords: Double-strand breaks; Homologous recombination; RNA methylation; Therapeutic resistance.

Publication types

Review

MeSH terms

Drug Resistance, Neoplasm* / genetics
Histones / genetics
Humans
Methylation
RNA
Recombinational DNA Repair*

Substances

Histones
RNA