Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 group F virus following serial passage in humanized mice

James Z Curlin; Kimberly Schmitt; Leila Remling-Mulder; Corina Valencia Tibbitts; Shelby O'Connor; Preston Marx; Ramesh Akkina

doi:10.1111/jmp.12674

Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 group F virus following serial passage in humanized mice

J Med Primatol. 2023 Oct;52(5):290-293. doi: 10.1111/jmp.12674. Epub 2023 Sep 1.

Authors

James Z Curlin^{1

2}, Kimberly Schmitt¹, Leila Remling-Mulder¹, Corina Valencia Tibbitts³, Shelby O'Connor³, Preston Marx^{4

5}, Ramesh Akkina¹

Affiliations

¹ Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
² ADEAR Training Program, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
³ Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
⁴ Department of Tropical Medicine, School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
⁵ Tulane National Primate Research Center, Covington, Louisiana, USA.

PMID: 37658590
PMCID: PMC10635500 (available on 2024-10-01)
DOI: 10.1111/jmp.12674

Abstract

HIV-2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu-mice showed increased viral loads, CD4⁺ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.

Keywords: HIV-2 group F; hu-HSC mice and HIV evolution; humanized mice; serial passaging; viral evolution.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
HIV-2* / genetics
Humans
Mice
Serial Passage
Viral Load

Abstract

Publication types

MeSH terms

Grants and funding