Lipid and renal profile in assessing the severity of alcoholic liver disease

Chitrasivasankari G; Gomathi V; Nachiappan R; Gurumoorthy Kaarthikeyan; Mahalakshmi S

doi:10.6026/973206300181036

Lipid and renal profile in assessing the severity of alcoholic liver disease

Bioinformation. 2022 Oct 31;18(10):1036-1040. doi: 10.6026/973206300181036. eCollection 2022.

Authors

Chitrasivasankari G¹, Gomathi V¹, Nachiappan R¹, Gurumoorthy Kaarthikeyan², Mahalakshmi S³

Affiliations

¹ Institute of Biochemistry, Madras Medical College, RGGGH, Chennai, India.
² Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai - 77, India.
³ Department of Biochemistry, Madurai Medical College, Madurai, Tamilnadu, India.

Abstract

Lipid and Renal dysfunction in Alcoholic liver disease (ALD) patients occurs either due to multi-organ involvement or secondary to alcoholism. This study was conducted to evaluate the role of lipid and renal parameters in assessing the severity of progression of ALD. Sixty cases of ALD (two groups based on compensated and decompensated features) and thirty healthy controls for comparison were included. Lipid profile (Total Cholesterol, LDL, HDL and Triglycerides) and renal parameters (serum urea, creatinine and uric acid), total and direct bilirubin, total protein and albumin were measured using automated chemistry analyzer. There was a significant decrease in Total cholesterol ,LDL and HDL levels and increased triglycerides when compared to controls (mean of 128.4 ± 59 vs 155 ± 27.2, 77 ± 44.3 vs 97.4 ± 27.2, 28.3 ± 18 vs 39.5 ± 14.1 and 115.8 ± 70.4 vs 91 ± 38 mg/dL respectively). Lipid profile showed a linear decrease while progressing from compensated to decompensated ALD. Renal parameters revealed a statistically significant decrease in serum urea ,increased creatinine and uric acid levels when compared to controls (17.57±2.96 vs23.73±4.94, 1.12±0.55 vs0.88±0.16,6.60±1.32 vs 4.68±1.40 mg/dL respectively).Total cholesterol and HDL showed a linear decrease when ALD progresses. Serum uric acid showed an early increase in compensated stage of ALD. This study inferred that Total cholesterol, TGL, HDL and uric acid can be used for assessing the severity of progression of ALD.

Keywords: Alcoholic liver disease; health; hepato-renal syndrome; lipid profile.