Cardiac Resynchronisation with Conduction System Pacing

Fatima M Ezzeddine; Isaac G Leon; Yong-Mei Cha

doi:10.15420/aer.2023.03

Cardiac Resynchronisation with Conduction System Pacing

Arrhythm Electrophysiol Rev. 2023 Aug 11:12:e22. doi: 10.15420/aer.2023.03. eCollection 2023.

Authors

Fatima M Ezzeddine¹, Isaac G Leon², Yong-Mei Cha¹

Affiliations

¹ Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, US.
² Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, US.

Abstract

To date, biventricular pacing (BiVP) has been the standard pacing modality for cardiac resynchronisation therapy. However, it is non-physiological, with the activation spreading between the left ventricular epicardium and right ventricular endocardium. Up to one-third of patients with heart failure who are eligible for cardiac resynchronisation therapy do not derive benefit from BiVP. Conduction system pacing (CSP), which includes His bundle pacing and left bundle branch area pacing, has emerged as an alternative to BiVP for cardiac resynchronisation. There is mounting evidence supporting the benefits of CSP in achieving synchronous ventricular activation and repolarisation. The aim of this review is to summarise the current options and outcomes of CSP when used for cardiac resynchronisation in patients with heart failure.

Keywords: Cardiac resynchronisation therapy; His bundle pacing; conduction system pacing; heart failure; left bundle branch area pacing; physiologic pacing.

Publication types

Review