Determining the pairing symmetry of single-layer FeSe on SrTiO3 is the key to understanding the enhanced pairing mechanism. It also guides the search for superconductors with high transition temperatures. Despite considerable efforts, it remains controversial whether the symmetry is the sign-preserving s- or the sign-changing s±-wave. Here, we investigate the pairing symmetry of single-layer FeSe from a topological point of view. Using low-temperature scanning tunneling microscopy/spectroscopy, we systematically characterize the superconducting states at edges and corners of single-layer FeSe. The tunneling spectra collected at edges and corners show a full energy gap and a substantial dip, respectively, suggesting the absence of topologically non-trivial edge and corner modes. According to our theoretical calculations, these spectroscopic features can be considered as strong evidence for the sign-preserving s-wave pairing in single-layer FeSe.
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