Honeybee as a food nutrition analysis model of neural development and gut microbiota

Yajun Huang; Na Li; Chengfeng Yang; Yan Lin; Yuxi Wen; Lingjun Zheng; Chao Zhao

doi:10.1016/j.neubiorev.2023.105372

Honeybee as a food nutrition analysis model of neural development and gut microbiota

Neurosci Biobehav Rev. 2023 Oct:153:105372. doi: 10.1016/j.neubiorev.2023.105372. Epub 2023 Aug 29.

Authors

Yajun Huang¹, Na Li¹, Chengfeng Yang², Yan Lin³, Yuxi Wen⁴, Lingjun Zheng⁵, Chao Zhao⁶

Affiliations

¹ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
² Department of Entomology, College of Plant Protection, China Agricultural University, Beijing 100193, China.
³ College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
⁴ College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Department of Analytical and Food Chemistry, Faculty of Sciences, Universidade de Vigo, 32004 Ourense, Spain.
⁵ School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: lingjunzheng@sjtu.edu.cn.
⁶ College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: zhchao@live.cn.

PMID: 37652394
DOI: 10.1016/j.neubiorev.2023.105372

Abstract

Research on the relationships between the gut microbiota and the neurophysiology and behavior of animals has grown exponentially in just a few years. Insect behavior may be controlled by molecular mechanisms that are partially homologous to those in mammals, and swarming insects may be suitable as experiment models in these types of investigations. All core gut bacteria in honeybees can be cultivated in vitro. Certain gut microflora of bees can be genetically engineered or sterilized and colonized. The bee gut bacteria model is established more rapidly and has a higher flux than other sterile animal models. It may help elucidate the pathogenesis of intestinal diseases and identify effective molecular therapeutic targets against them. In the present review, we focused on the contributions of the honeybee model in learning cognition and microbiome research. We explored the relationship between honeybee behavior and neurodevelopment and the factors determining the mechanisms by which the gut microbiota affects the host. In particular, we concentrated on the correlation between gut microbiota and brain development. Finally, we examined strategies for the effective use of simple animal models in animal cognition and microbiome research.

Keywords: Gut microbiota; Honeybee; Neurodevelopment; Omics application.

Publication types

Review