Cytomegalovirus (CMV) as a cause of exacerbation of ulcerative colitis (UC). An approach to diagnosis and management

Soma Dutta; Ujjwayini Ray

doi:10.1016/j.ijmmb.2023.100469

Cytomegalovirus (CMV) as a cause of exacerbation of ulcerative colitis (UC). An approach to diagnosis and management

Indian J Med Microbiol. 2023 Nov-Dec:46:100469. doi: 10.1016/j.ijmmb.2023.100469. Epub 2023 Aug 30.

Authors

Soma Dutta¹, Ujjwayini Ray²

Affiliations

¹ Microbiology, Serology and Molecular biology, Apollo Multi-speciality Hospitals, Kolkata, India. Electronic address: dr.somadutta@gmail.com.
² Microbiology, Serology and Molecular biology, Apollo Multi-speciality Hospitals, Kolkata, India.

PMID: 37651763
DOI: 10.1016/j.ijmmb.2023.100469

Abstract

Cytomegalovirus (CMV) reactivation may be a cause of acute exacerbations in patients with severe ulcerative colitis (UC). Patients with exacerbation of symptoms by CMV have greater morbidity and mortality rate. The present study was conducted to evaluate the prevalence of CMV infection in UC patients by endoscopic examination, histopathological examination and CMV DNA PCR of colonic mucosal biopsy tissue and also to identify the associated risk factors and clinical outcomes.

Keywords: CMV reactivation; Colonic mucosal biopsy; Cytomegalovirus (CMV); Polymerase chain reaction (PCR); Ulcerative colitis(UC).

MeSH terms

Colitis, Ulcerative* / diagnosis
Cytomegalovirus / genetics
Cytomegalovirus Infections* / complications
Cytomegalovirus Infections* / diagnosis
Cytomegalovirus Infections* / drug therapy
Humans
Risk Factors