Unanswered questions about the causes of obesity

Science. 2023 Sep;381(6661):944-946. doi: 10.1126/science.adg2718. Epub 2023 Aug 31.

John R Speakman^{1

2

3

4}, Thorkild I A Sørensen^{5

6}, Kevin D Hall⁷, David B Allison⁸

¹ Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
² School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland, UK.
³ State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
⁴ China Medical University, Shenyang, Liaoning, China.
⁵ Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
⁶ Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
⁷ National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
⁸ School of Public Health, Indiana University, Bloomington, IN, USA.

Abstract

Obesity is now a global pandemic, but there is little consensus about the causes.