Effects of anthocyanin supplementation on blood lipid levels: a systematic review and meta-analysis

Hwan-Hee Jang; In-Guk Hwang; Young-Min Lee

doi:10.3389/fnut.2023.1207751

Effects of anthocyanin supplementation on blood lipid levels: a systematic review and meta-analysis

Front Nutr. 2023 Aug 15:10:1207751. doi: 10.3389/fnut.2023.1207751. eCollection 2023.

Authors

Hwan-Hee Jang¹, In-Guk Hwang¹, Young-Min Lee²

Affiliations

¹ Functional Food Division, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, Republic of Korea.
² Department of Practical Science Education, Gyeongin National University of Education, Incheon, Republic of Korea.

Abstract

Introduction: Dyslipidemia is a major cardiovascular disease risk factor associated with increased mortality. The intake of plant food-derived bioactive compounds is associated with beneficial cardiovascular effects, including decreased blood lipid levels and cardiovascular risk. We aimed to evaluate the effects of anthocyanin intake on blood lipid levels by analyzing relevant randomized controlled trials.

Methods: We searched the PubMed and Embase databases using the "Patient/Population, Intervention, Comparison, and Outcomes" format to determine whether anthocyanin supplementation intervention affected blood lipid levels compared with placebo supplementation in human participants.

Results: A total of 41 studies with 2,788 participants were included in the meta-analysis. Anthocyanin supplementation significantly reduced triglyceride [standardized mean difference (SMD) = -0.10; 95% confidence interval [CI], -0.18, -0.01) and low-density lipoprotein-cholesterol (SMD = -0.16; 95% CI -0.26, -0.07) levels and increased high-density lipoprotein-cholesterol levels (SMD = 0.42; 95% CI 0.20, 0.65).

Discussion: Anthocyanin supplementation significantly improved blood lipid component levels in the included studies. Larger, well-designed clinical trials are needed to further investigate the effects of anthocyanin intake on blood lipid levels and the safety of anthocyanin supplementation for treating dyslipidemia.

Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021257087, identifier: CRD42021257087.

Keywords: HDL cholesterol; dyslipidemia; food supplementation; metabolic syndrome; triglyceride.

Publication types

Systematic Review

Grants and funding

This research was supported by the research program for Agricultural Science & Technology Development under the National Institute of Agricultural Science (NAS)-Rural Development Administration (RDA), South Korea, under grant numbers PJ01420101 and PJ01703102.