Transcriptional repressor GATA binding 1 (TRPS1) immunoexpression in normal skin tissues and various cutaneous tumors

Kohei Taniguchi; Keisuke Goto; Hiroki Yabushita; Rie Yamasaki; Koichi Ichimura

doi:10.1111/cup.14523

Transcriptional repressor GATA binding 1 (TRPS1) immunoexpression in normal skin tissues and various cutaneous tumors

J Cutan Pathol. 2023 Nov;50(11):1006-1013. doi: 10.1111/cup.14523. Epub 2023 Aug 30.

Authors

Kohei Taniguchi¹, Keisuke Goto^{2

3

4

5

6

7

8

9

10}, Hiroki Yabushita¹, Rie Yamasaki¹, Koichi Ichimura¹

Affiliations

¹ Department of Pathology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
² Department of Pathology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo, Japan.
³ Department of Pathology, Itabashi Central Clinical Laboratory, Tokyo, Japan.
⁴ Department of Diagnostic Pathology, Tokyo Medical University Hospital, Tokyo, Japan.
⁵ Department of Diagnostic Pathology, Shizuoka Cancer Center Hospital, Sunto, Japan.
⁶ Department of Diagnostic Pathology, Chutoen General Medical Center, Kakegawa, Japan.
⁷ Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Osaka, Japan.
⁸ Department of Diagnostic Pathology, Osaka National Hospital, Osaka, Japan.
⁹ Department of Dermatology, Hyogo Cancer Center, Akashi, Japan.
¹⁰ Department of Dermato-Oncology/Dermatology, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.

PMID: 37649299
DOI: 10.1111/cup.14523

Abstract

Background: Transcriptional repressor GATA binding 1 (TRPS1) is a transcription factor recently shown to play a role in the development of breast and liver cancer. Here, we evaluate TRPS1 immunoexpression in normal skin tissues and various cutaneous tumors.

Methods: TRPS1 immunohistochemistry was performed in 109 cases of primary cutaneous tumors and 19 cases of metastatic carcinomas. TRPS1 expression was also evaluated in the normal skin tissues.

Results: The normal epidermis was TRPS1-. In contrast, the eccrine apparatus, epithelial compartment of the hair follicles, hair papilla, sebaceous glands, and anogenital mammary-like glands were TRPS1+. In primary cutaneous tumors, TRPS1 positivity varied in poroma (2/3), nodular hidradenoma (4/5), spiradenoma (4/4), cutaneous mixed tumor (5/5), trichilemmal cyst (7/8), proliferating trichilemmal tumor (1/3), pilomatricoma (9/9), sebaceoma (2/5), extramammary Paget disease (13/13), sebaceous carcinoma (2/2), actinic keratosis (3/10), Bowen disease (7/12), and squamous cell carcinoma (1/5) cases. All cases of seborrheic keratosis, basal cell carcinoma, Merkel cell carcinoma, and malignant melanoma were TRPS1-. All metastatic breast carcinoma cases (8/8) were highly positive for TRPS1, while all but one of the other metastatic tumor cases were TRPS1-.

Conclusions: TRPS1 immunoexpression was observed in several skin appendages and cutaneous tumors.

Keywords: TRPS1; cutaneous adnexal tumors; immunohistochemistry; skin; skin tumors.