Interventions to prevent miscarriage

Fertil Steril. 2023 Nov;120(5):951-954. doi: 10.1016/j.fertnstert.2023.08.955. Epub 2023 Aug 28.

Abstract

The physical and psychological impact of miscarriage can be devastating. There are many lifestyle and therapeutic interventions that may prevent a miscarriage. In this review, we have outlined the key areas for health optimization to prevent pregnancy loss, drawing on the most up-to-date evidence available. The 3 key areas identified are lifestyle optimization in women, lifestyle optimization in men, and therapeutic interventions. The evidence demonstrates that the treatments to consider are first-trimester progesterone administration, levothyroxine in women with subclinical hypothyroidism, and the combination of aspirin and heparin in women with antiphospholipid antibodies.

Keywords: Interventions; miscarriage; pregnancy loss.

Publication types

  • Review

MeSH terms

  • Abortion, Habitual* / prevention & control
  • Abortion, Spontaneous* / drug therapy
  • Abortion, Spontaneous* / etiology
  • Abortion, Spontaneous* / prevention & control
  • Aspirin / therapeutic use
  • Female
  • Heparin / therapeutic use
  • Humans
  • Hypothyroidism*
  • Pregnancy
  • Thyroxine / therapeutic use

Substances

  • Aspirin
  • Heparin
  • Thyroxine