Introduction: Interleukin-38 (IL-38) is a new type of anti-inflammatory cytokine, which is mainly expressed in the immunity-related organs and is involved in various diseases including cardiovascular and cerebrovascular diseases, lung diseases, viral infectious diseases and autoimmune diseases.
Aim: This review aims to detail the biological function, receptors and signaling of IL-38, which highlights its therapeutic potential in related diseases.
Conclusion: This article provides a comprehensive review of the association between interleukin-38 and related diseases, using interleukin-38 as a keyword and searching the relevant literature through Pubmed and Web of science up to July 2023.
Keywords: cardiovascular and cerebrovascular diseases; interleukin-38; lung diseases; signal path; viral infectious diseasesautoimmune diseases.
© 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.