Interrelation between the lipid accumulation product index and diabetic kidney disease in patients with type 2 diabetes mellitus

Min Tang; Shuangshuang Yao; Han Cao; Xiaohui Wei; Qin Zhen; Yijiong Tan; Fang Liu; Yufan Wang; Yongde Peng; Nengguang Fan

doi:10.3389/fendo.2023.1224889

Interrelation between the lipid accumulation product index and diabetic kidney disease in patients with type 2 diabetes mellitus

Front Endocrinol (Lausanne). 2023 Aug 14:14:1224889. doi: 10.3389/fendo.2023.1224889. eCollection 2023.

Authors

Min Tang¹, Shuangshuang Yao¹, Han Cao^{2

3}, Xiaohui Wei¹, Qin Zhen¹, Yijiong Tan⁴, Fang Liu¹, Yufan Wang¹, Yongde Peng^{1

2}, Nengguang Fan¹

Affiliations

¹ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Department of Endocrinology and Metabolism, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
³ Department of Endocrinology, Songjiang District Central Hospital, Shanghai, China.
⁴ Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

Objective: The purpose of this study was to determine the relation between the lipid accumulation product index (LAPI) and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).

Methods: Herein, 931 patients were enrolled and their data were collected. Then the interrelation between LAPI and DKD was assessed using multivariate logistic regression analyses (LRAs) and by a restricted cubic spline (RCS).

Results: In total, 931 participants (352 females and 579 males) aged 55 years on average were included in the study. After adjusting for several confounders, the odds ratio for DKD was increased evidently in the third LAPI tertile compared with that in the first LAPI tertile. In addition, the RCS revealed a positive interrelation between LAPI and DKD. In the subgroup analyses, age, sex, hyperlipidemia, hypertension, and HbA1c did not significantly interact with LAPI.

Conclusions: LAPI was higher in the DKD group than in the no-DKD group, and LAPI is positively linked with DKD, which may have potential value to diagnose DKD in clinical practice.

Keywords: abdominal obesity; diabetic kidney disease; lipid accumulation product; restricted cubic spline; type 2 diabetes mellitus.

MeSH terms

Diabetes Mellitus, Type 2* / complications
Diabetic Nephropathies* / diagnosis
Diabetic Nephropathies* / etiology
Female
Humans
Hypertension*
Lipid Accumulation Product*
Male
Odds Ratio

Grants and funding

This study was supported by the National Natural Science Foundation of China (81870596, 82170827, 82170829, 82200639), the Natural Science Foundation of Shanghai (21ZR1451200, 22ZR1450100), clinical research plan of SHDC (SHDC2020CR1016B) and Science and Technology Research Project in Songjiang District (22SJKGGG17).