Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging

Yang Xie; Huayi Wu; Ziyan Chen; Qi Sun; Xiangdong Liu; Jinsheng Jiang; Bo Wang; Zeyu Chen

doi:10.1016/j.pacs.2023.100530

Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging

Photoacoustics. 2023 Jul 15:32:100530. doi: 10.1016/j.pacs.2023.100530. eCollection 2023 Aug.

Authors

Yang Xie¹, Huayi Wu¹, Ziyan Chen¹, Qi Sun¹, Xiangdong Liu¹, Jinsheng Jiang², Bo Wang², Zeyu Chen¹

Affiliations

¹ School of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
² Department of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, China.

Abstract

Transdermal drug delivery (TDD) is less invasive and avoids first-pass metabolism, making it an attractive method for treating various diseases such as diabetes and hypertension. However, current methods for evaluating TDD systems lack in vivo descriptions of drug distribution in the skin. In this study, we demonstrate the capability of the Transient Triplet Differential (TTD) method, a non-invasive and background-free photoacoustic imaging technique, for accurately mapping drug distribution and evaluating different TDD systems. Our findings show that the TTD method can provide high sensitivity and specificity for targeted drug extraction and visualize 3D drug distribution in the skin. Furthermore, in vivo experiments confirmed the potential of the TTD method in evaluating the clinical performance of TDD. It's predictable that the TTD method can be a reliable and non-invasive approach for evaluating TDD systems and offer valuable insights into TDD research and development.

Keywords: 3D imaging; Background-free; Evaluation of transdermal drug delivery; Non-invasive; Photoacoustic imaging; Transient triplet differential (TTD) method.