It is difficult to model in vitro the intestine when seeking to include crosstalk with the gut microbiota, immune and neuroendocrine systems. Here we present a roadmap of the current models to facilitate the choice in preclinical and translational research with a focus on gut-on-chip. These micro physiological systems (MPS) are microfluidic devices that recapitulate in vitro the physiology of the intestine. We reviewed the gut-on-chips that had been developed in academia and industries as single chip and that have three main purpose: replicate the intestinal physiology, the intestinal pathological features, and for pharmacological tests.
Keywords: Colon-on-a-chip; Gut-on-a-chip; Intestine-on-a-chip; Microbiota-on-a-chip; Organ-on-a-chip; intestinal models; microfluidic.
Copyright: © 2023 Malaguarnera G et al.