Long non-coding RNAs (lncRNAs) are strongly related to the occurrence and development of digestive tract cancer in human. Firstly, lncRNAs target and regulate the expression of downstream cancer genes to affect the growth, metastasis, apoptosis, metabolism and immune escape of cancer cells. Secondly, lncRNAs are considered to be important regulating factors for lipid metabolism in cancer, which is related to signaling pathways of adipogenesis and involved in the occurrence and development of digestive tract cancer. Finally, lncRNAs have application value in the diagnosis and treatment of digestive tract cancer. For example, lncRNAMALAT1 has been reported as a target for diagnosis and treatment of hepatocellular carcinoma. This article reviews current progress on the regulatory role of lncRNAs in digestive tract cancer, to provide references for the research and clinical application in the prevention and treatment of digestive tract cancer.
长链非编码RNA（lncRNA）与人类消化道癌症的发生发展高度相关。首先，lncRNA通过靶向调控下游癌症基因表达，影响癌细胞的生长、转移、凋亡、代谢和免疫逃逸等，调节消化道癌症的发生和发展。其次，lncRNA也是癌症进展中调控脂代谢的重要因子，可以调控癌细胞的脂肪生成及其相关信号通路，从而影响消化道癌症发生发展。最后，lncRNA在消化道癌症的诊断及治疗中有一定应用价值，如lncRNAMALAT1可以作为肝细胞癌诊断和治疗靶点。本文梳理并总结了近些年关于lncRNA在消化道癌症及其脂代谢中的调控作用，为消化道癌症的防治研究提供理论依据。.
Keywords: Digestive tract cancer; Lipid metabolism; Long non-coding RNA; Review; Signaling pathway; Targeted therapy.