Roles of MT-ND1 in Cancer

Yi-Chun Xu; Jun Su; Jia-Jing Zhou; Qing Yuan; Jun-Song Han

doi:10.1007/s11596-023-2771-0

Roles of MT-ND1 in Cancer

Curr Med Sci. 2023 Oct;43(5):869-878. doi: 10.1007/s11596-023-2771-0. Epub 2023 Aug 29.

Authors

Yi-Chun Xu^{1

2}, Jun Su^{3

4}, Jia-Jing Zhou³, Qing Yuan³, Jun-Song Han^{5

6}

Affiliations

¹ Department of Pathology, Shanghai Tongji Hospital, Tongji Hospital Affiliated to Tongji University, Shanghai, 200065, China. crystalxyc@hotmail.com.
² National Engineering Research Center for Biochip, Shanghai Biochip Limited Corporation, Shanghai, 201203, China. crystalxyc@hotmail.com.
³ Department of Pathology, Shanghai Tongji Hospital, Tongji Hospital Affiliated to Tongji University, Shanghai, 200065, China.
⁴ National Engineering Research Center for Biochip, Shanghai Biochip Limited Corporation, Shanghai, 201203, China.
⁵ Department of Pathology, Shanghai Tongji Hospital, Tongji Hospital Affiliated to Tongji University, Shanghai, 200065, China. junsong_han@shbiochip.com.
⁶ National Engineering Research Center for Biochip, Shanghai Biochip Limited Corporation, Shanghai, 201203, China. junsong_han@shbiochip.com.

PMID: 37642864
DOI: 10.1007/s11596-023-2771-0

Abstract

The energy shift toward glycolysis is one of the hallmarks of cancer. Complex I is a vital enzyme complex necessary for oxidative phosphorylation. The mitochondrially encoded NADH: ubiquinone oxidoreductase core subunit 1 (MT-ND1) is the largest subunit coded by mitochondria of complex I. The present study summarizes the structure and biological function of MT-ND1. From databases and literature, the expressions and mutations of MT-ND1 in a variety of cancers have been reviewed. MT-ND1 may be a biomarker for cancer diagnosis and prognosis. It is also a potential target for cancer therapy.

Keywords: biomarker; cancer; mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1; mutation.