Research Progress of Tamarixetin and its glycosides

Cunbing Li; Mengxin Tao; Tingting Li; Xiaofen Huang; Hong Sui; Xueyan Fu

doi:10.2174/1389557523666230828123425

Research Progress of Tamarixetin and its glycosides

Mini Rev Med Chem. 2023 Aug 28. doi: 10.2174/1389557523666230828123425. Online ahead of print.

Authors

Cunbing Li¹, Mengxin Tao¹, Tingting Li², Xiaofen Huang², Hong Sui¹, Xueyan Fu^{1

2}

Affiliations

¹ School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
² Ningxia Minority Medicine Modernization Key Laboratory of Ministry of Education, Yinchuan 75004, China.

PMID: 37642001
DOI: 10.2174/1389557523666230828123425

Abstract

Tamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, anti-inflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1976 to 2023 are obtained from PubMed, China Knowledge Base Database, Wanfang Data, and other electronic databases. Tamarixetin is searched based on keywords, and 121 articles remain. Transformation synthesis, pharmacokinetics, pharmacological action, and structure-activity relationship of tamarixetin were reviewed.

Keywords: pharmacokinetics; pharmacological action; structure-activity relationship; tamarixetin; tamarixetin glycoside; transformation synthesis.