[Research progress on the treatment improvement of HPV-associated oropharyngeal cancer]

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023 Sep;37(9):740-747. doi: 10.13201/j.issn.2096-7993.2023.09.010.
[Article in Chinese]

Abstract
in English, Chinese

The number of new cases of oropharyngeal cancer is increasing year by year among the world, and HPV infection is one of the risk factors for this malignant tumor. Compared with HPV-negative oropharyngeal cancer, HPV-positive patients are more sensitive to radiotherapy and have a better prognosis, but there is no accepted treatment for HPV-positive patients. Reducing treatment intensity moderately and exploring the best option to minimize side effects of treatment are urgent issues to be addressed. This article reviews the research progress on the treatment improvement of HPV-associated oropharyngeal cancer in recent years.

摘要: 全球范围内口咽癌的新发患者正逐年增加，HPV感染是导致此类恶性肿瘤的危险因素。相较于HPV阴性的口咽癌，HPV阳性患者对放化疗更加敏感，且具有更好的预后，但目前并没有针对于HPV阳性患者公认的治疗方案。适当降低HPV阳性口咽癌的治疗强度，探索最佳的治疗方案以减少治疗的毒副反应，是亟待解决的临床问题。本文就近年来HPV阳性口咽癌患者治疗方法改进的研究进展进行综述。.

Keywords: human papillomavirus（HPV）; oropharyngeal cancer; reducing treatment intensity.

Publication types

  • Review
  • English Abstract

MeSH terms

  • Humans
  • Oropharyngeal Neoplasms* / therapy
  • Papillomavirus Infections*
  • Risk Factors