Fluorogenic chemically induced dimerization

Wenjing Wang; Jiaqi Shen

doi:10.1038/s41592-023-01989-7

Fluorogenic chemically induced dimerization

Nat Methods. 2023 Oct;20(10):1454-1455. doi: 10.1038/s41592-023-01989-7.

Authors

Wenjing Wang^{1

2}, Jiaqi Shen^{3

4}

Affiliations

¹ Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. wenjwang@umich.edu.
² Department of Chemistry, University of Michigan, Ann Arbor, MI, USA. wenjwang@umich.edu.
³ Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
⁴ Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.

Abstract

A new chemically induced dimerization (CID) pair exhibits fluorescence upon dimerization for the first time. Moreover, the CID pair is small in size and offers easily reversible dimerization that can be repeated multiple times.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Comment

MeSH terms

Dimerization
Fluorescent Dyes*

Substances

Fluorescent Dyes

Grants and funding

DP2 MH132939/MH/NIMH NIH HHS/United States