Targeting helminths: The expanding world of type 2 immune effector mechanisms

Rick M Maizels; William C Gause

doi:10.1084/jem.20221381

Targeting helminths: The expanding world of type 2 immune effector mechanisms

J Exp Med. 2023 Oct 2;220(10):e20221381. doi: 10.1084/jem.20221381. Epub 2023 Aug 28.

Authors

Rick M Maizels¹, William C Gause²

Affiliations

¹ Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK.
² Center for Immunity and Inflammation, Rutgers Biomedical Health Sciences Institute for Infectious and Inflammatory Diseases, New Jersey Medical School, Rutgers Biomedical Health Sciences, Newark, NJ, USA.

Abstract

In this new review, Rick Maizels and Bill Gause summarize how type 2 immune responses combat helminth parasites through novel mechanisms, coordinating multiple innate and adaptive cell and molecular players that can eliminate infection and repair-resultant tissue damage.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Helminthiasis* / immunology
Helminths*

Abstract

Publication types

MeSH terms

Grants and funding