Histone deacetylase 6's function in viral infection, innate immunity, and disease: latest advances

Min Qu; Huijun Zhang; Pengyuan Cheng; Ashenafi Kiros Wubshet; Xiangping Yin; Xiangwei Wang; Yuefeng Sun

doi:10.3389/fimmu.2023.1216548

Histone deacetylase 6's function in viral infection, innate immunity, and disease: latest advances

Front Immunol. 2023 Aug 11:14:1216548. doi: 10.3389/fimmu.2023.1216548. eCollection 2023.

Authors

Min Qu¹, Huijun Zhang¹, Pengyuan Cheng¹, Ashenafi Kiros Wubshet^{1

2}, Xiangping Yin¹, Xiangwei Wang¹, Yuefeng Sun¹

Affiliations

¹ State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
² Department of Basic and Diagnostic Sciences, College of Veterinary Science, Mekelle University, Mekelle, Tigray, Ethiopia.

Abstract

In the family of histone-deacetylases, histone deacetylase 6 (HDAC6) stands out. The cytoplasmic class IIb histone deacetylase (HDAC) family is essential for many cellular functions. It plays a crucial and debatable regulatory role in innate antiviral immunity. This review summarises the current state of our understanding of HDAC6's structure and function in light of the three mechanisms by which it controls DNA and RNA virus infection: cytoskeleton regulation, host innate immune response, and autophagy degradation of host or viral proteins. In addition, we summed up how HDAC6 inhibitors are used to treat a wide range of diseases, and how its upstream signaling plays a role in the antiviral mechanism. Together, the findings of this review highlight HDAC6's importance as a new therapeutic target in antiviral immunity, innate immune response, and some diseases, all of which offer promising new avenues for the development of drugs targeting the immune response.

Keywords: HDAC6; autophagy; diseases; innate immunity; viral infection.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Histone Deacetylase 6*
Humans
Immunity, Innate*
Virus Diseases* / drug therapy

Substances

Histone Deacetylase 6
HDAC6 protein, human

Grants and funding

This work was sponsored by the Major Science and Technology Project of Gansu Province (21ZD3NA001, 22ZD6NA001), the Key Development and Research Foundation of Gansu (Grant no. 21YF5WA153) and National Natural Science Foundation of China (Grant no. 32202779).