Primary clear cell adenocarcinoma of the vagina not associated with diethylstilbestrol metastasizing to the lung: a case report

Abdelhamid Benlghazi; Moad Belouad; Hamza Messaoudi; Saad Benali; Rachid Aitbouhou; El Mangoub Fatima; Mly Mehdi Elhassani; Jaouad Kouach

doi:10.1093/omcr/omad080

Primary clear cell adenocarcinoma of the vagina not associated with diethylstilbestrol metastasizing to the lung: a case report

Oxf Med Case Reports. 2023 Aug 20;2023(8):omad080. doi: 10.1093/omcr/omad080. eCollection 2023 Aug.

Authors

Abdelhamid Benlghazi¹, Moad Belouad¹, Hamza Messaoudi¹, Saad Benali¹, Rachid Aitbouhou¹, El Mangoub Fatima¹, Mly Mehdi Elhassani¹, Jaouad Kouach¹

Affiliation

¹ Department of Gynecology and Obstetrics Military Hospital Mohammed V Rabat, Faculty of Medicine and Pharmacy of Rabat, University Mohammed V, Rabat, Morocco.

Abstract

Primary clear cell carcinoma of the vagina (PCCAV) is a rare form of vaginal cancer that typically affects young women with a history of prenatal exposure to DES. However, data on non-DES PCCAV cases are limited. This report describes a case of PCCAV in a 47-year-old patient who presented with post-coital bleeding and was diagnosed with clear cell adenocarcinoma via biopsy and MRI. The patient had no history of DES exposure and further testing showed no signs of metastasis, leading to surgery and chemotherapy. Four years later, the patient presented with dyspnea, and a chest CT scan revealed a lung nodule, later confirmed to be a metastasis of clear cell adenocarcinoma from the vaginal cancer. The patient passed away a month later due to complications from COVID-19.

Publication types

Case Reports