Cancer cell membrane-coated upconversion nanoparticles/ZnxMn1-xS core-shell nanoparticles for targeted photodynamic and chemodynamic therapy of pancreatic cancer

Xiaoyan Liu; Zhaoyou Chu; Benjin Chen; Yan Ma; Lingling Xu; Haisheng Qian; Yue Yu

doi:10.1016/j.mtbio.2023.100765

Cancer cell membrane-coated upconversion nanoparticles/Zn_xMn_1-xS core-shell nanoparticles for targeted photodynamic and chemodynamic therapy of pancreatic cancer

Mater Today Bio. 2023 Aug 14:22:100765. doi: 10.1016/j.mtbio.2023.100765. eCollection 2023 Oct.

Authors

Xiaoyan Liu^{1

2

3}, Zhaoyou Chu^{4

5}, Benjin Chen^{4

5}, Yan Ma⁵, Lingling Xu⁵, Haisheng Qian⁵, Yue Yu^{1

2}

Affiliations

¹ Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, PR China.
² Department of Gastroenterology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, PR China.
³ Department of Gastroenterology, The Lu'an Hospital Affiliated to Anhui Medical University, The Lu'an People's Hospital, Lu'an, Anhui, 237000, PR China.
⁴ Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, 230032, PR China.
⁵ School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, 230032, PR China.

Abstract

Oxidative stress induced by reactive oxygen species (ROS) is promising treatment approach for pancreatic ductal adenocarcinoma (PDAC), which is typically insensitive to conventional chemotherapy. In this study, BxPC-3 pancreatic cancer cell membrane-coated upconversion nanoparticles/Zn_xMn_1-xS core-shell nanoparticles (abbreviated as BUC@ZMS) were developed for tumor-targeted cancer therapy via synergistically oxidative stress and overcoming glutathione (GSH) overexpression. Using a combination of photodynamic therapy (PDT) and chemodynamic therapy (CDT), the BUC@ZMS core-shell nanoparticles were able to elicit the death of pancreatic cancer cells through the high production of ROS. Additionally, the BUC@ZMS core-shell nanoparticles could deplete intracellular GSH and increase the sensitivity of tumor cells to oxidative stress. The in vivo results indicated that BUC@ZMS nanoparticles can accumulate specifically in tumor locations and suppress PDAC without generating obvious toxicity. Thus, it was determined that the as-prepared core-shell nanoparticles would be a viable treatment option for solid malignancies.

Keywords: Biomimetic nanoparticles; Chemodynamic therapy; Pancreatic ductal adenocarcinomas; Photodynamic therapy; Upconversion nanoparticles.