Comparative Survival Function in Patients with Positive Surgical Margins Following Laryngectomy

Yılmaz Özkul; Ejder Ciğer; Mustafa Koray Balcı; Ahmet Erdem Kılavuz; Feda Bayrak; Murat Songu; Akif İşlek

doi:10.1007/s12070-023-03706-4

Comparative Survival Function in Patients with Positive Surgical Margins Following Laryngectomy

Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):1625-1630. doi: 10.1007/s12070-023-03706-4. Epub 2023 Mar 22.

Authors

Yılmaz Özkul¹, Ejder Ciğer², Mustafa Koray Balcı³, Ahmet Erdem Kılavuz⁴, Feda Bayrak¹, Murat Songu¹, Akif İşlek^{5

6}

Affiliations

¹ Department of Otolaryngology-Head & Neck Surgery, Izmir Katip Celebi University, İzmir, Turkey.
² Department of Otolaryngology-Head & Neck Surgery, Medical Park Hospital, İzmir Economy University, İzmir, Turkey.
³ Department of Otolaryngology-Head & Neck Surgery, Galen Hospital, Izmir Tinaztepe University, İzmir, Turkey.
⁴ Department of Otolaryngology-Head & Neck Surgery, Acıbadem Kozyatagi Hospital, Acibadem University, İstanbul, Turkey.
⁵ Department of Otolaryngology-Head & Neck Surgery, Biruni University, İstanbul, Turkey.
⁶ Department of Otolaryngology-Head & Neck Surgery, Eskişehir Acibadem Hospital, Acıbadem Street, 19, Eskibağlar, Hoşnudiye, 26130 Tepebaşı Eskişehir, Turkey.

PMID: 37636768
PMCID: PMC10447782 (available on 2024-09-01)
DOI: 10.1007/s12070-023-03706-4

Abstract

Aims: This study aims to make a comparative analysis of disease-free survival (DFS) and overall disease-specific survival (OS) in patients with laryngeal carcinoma. Materials and methods: The study was designed retrospectively. Sixteen patients with postoperative PSM and 30 with negative surgical margins (NSM) were included. Survival analysis and Long-Rank comparisons was performed for DFS and OS between groups. Results: PSM was a significant independent risk factor for loco-regional recurrence and disease-related mortality (p = 0.004, HR: 1.6, p = 0.002, HR: 3.2, respectively). DFS and OS were significantly longer in NSM group (p = 0.001 and 0.003, respectively). For PSM group, 2- and 5-year DFS rates were 57%; OS rates were 80% and 34% respectively. In NSM group, 2- and 5-year DFS rates were 96% and 83%; OS rates were found to be 96%. Conclusion: PSM had significant relation with poor prognosis.

Keywords: Laryngeal carcinoma; Prognosis; Recurrence; Surgical margin; Survival.

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