Outpatient Clinical Markers for Laryngopharyngeal Reflux Disease: A Correlational Study

Praveen Kumar Paramasivam; Pankaj Kumar Sahu; Tapasya Bishnoi; Angshuman Dutta; Mukesh Kumar Yadav; Sudheer Kumar Marlapudi

doi:10.1007/s12070-023-03805-2

Outpatient Clinical Markers for Laryngopharyngeal Reflux Disease: A Correlational Study

Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):2042-2048. doi: 10.1007/s12070-023-03805-2. Epub 2023 Apr 25.

Authors

Praveen Kumar Paramasivam¹, Pankaj Kumar Sahu¹, Tapasya Bishnoi¹, Angshuman Dutta¹, Mukesh Kumar Yadav¹, Sudheer Kumar Marlapudi¹

Affiliation

¹ Department of ENT, Command Hospital Airforce Bangalore, Cambridge Layout, AGARAM Post, Bangalore, Karnataka 560007 India.

PMID: 37636640
PMCID: PMC10447725 (available on 2024-09-01)
DOI: 10.1007/s12070-023-03805-2

Abstract

Laryngopharyngeal reflux disease (LPRD) is the result of retrograde flow of gastric contents to the laryngopharynx which comes in contact with tissues of the upper aerodigestive tract. Due to ill defined criteria for diagnosis & followup, LPRD patients are underdiagnosed & undertreated. Reflux Symptom Index (RSI) and the Reflux Finding Score (RFS) are two clinical methods which can be utilised especially in the outpatient setup. This study was done with the aim to assess various laryngoscopic findings in patients with LPRD diagnosed symptomatically and examine the correlation between the RSI & RFS by comparing these two indices. This prospective analytical study was conducted at a tertiary care centre in Bangalore in the Department of ENT for a period of 24 months between Dec 2020 to Dec 2022. The study included patients aged 18 to 60 years diagnosed with LPRD based on symptoms as per RSI score (> 13). RSI & RFS were assessed on diagnosis and patients were followed up for 1, 3 & 6 months for assessment. Total 96 patients were enrolled, with mean age of be 42.49 ± 11.33 years. Prevalence was found to be more in females (61.5%). The most common symptom according to RSI was frequent throat clearing & globus sensation (sensation of something sticking in throat) and most common finding according to RFS was erythema/hyperemia. The mean score of RSI and RFI was found to reduce with treatment at different intervals in follow-up visits. There was a significant strength of association between the RSI and RFS at baseline, 1st month, 3rd month and 6th month of follow-up (r = 0.568, r = 0.684, r = 0.774, r = 0.736 respectively) (p < 0.001).The RFS and RSI showed statistically significant strong relationships between total scores and sign and symptom characteristics. On follow-up, there was a significant reduction in the RSI which was also correlated with a reduction in RFS.

Keywords: Gastroesophageal reflux disease; Laryngopharyngeal reflux; Reflux Finding Score; Reflux Symptom Index.

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