Risk and prevalence of oral cancer in patients with different types of lupus erythematosus: a systematic review and meta-analysis

Larissa Rosa Santana Rodrigues; Daniel Lobato Ferreira Ferraz; Cecília Raquel Guimarães de Oliveira; Karine Evangelista; Maria Alves Garcia Silva; Fernanda Paula Yamamoto Silva; Brunno Santos de Freitas Silva

doi:10.1016/j.oooo.2023.07.007

Risk and prevalence of oral cancer in patients with different types of lupus erythematosus: a systematic review and meta-analysis

Oral Surg Oral Med Oral Pathol Oral Radiol. 2023 Nov;136(5):595-605. doi: 10.1016/j.oooo.2023.07.007. Epub 2023 Jul 12.

Authors

Larissa Rosa Santana Rodrigues¹, Daniel Lobato Ferreira Ferraz², Cecília Raquel Guimarães de Oliveira¹, Karine Evangelista¹, Maria Alves Garcia Silva³, Fernanda Paula Yamamoto Silva³, Brunno Santos de Freitas Silva⁴

Affiliations

¹ Department of Stomatologic Sciences, School of Dentistry, Federal University of Goiás, Goiânia, GO, Brazil.
² Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
³ Department of Stomatologic Sciences, School of Dentistry, Federal University of Goiás, Goiânia, GO, Brazil; Oral Diagnosis Department, Evangelical University of Goiás, Anápolis, GO, Brazil.
⁴ Department of Stomatologic Sciences, School of Dentistry, Federal University of Goiás, Goiânia, GO, Brazil; Oral Diagnosis Department, Evangelical University of Goiás, Anápolis, GO, Brazil. Electronic address: brunno_santos@ufg.br.

PMID: 37635011
DOI: 10.1016/j.oooo.2023.07.007

Abstract

Objective: The objective of this study was to assess the risk and prevalence of oral cancer in patients with systemic lupus erythematosus (SLE) or discoid lupus erythematosus (DLE).

Study design: The review included observational cohort and cross-sectional studies that investigated the incidence or prevalence of oral cancer in adults with confirmed diagnoses of SLE or DLE. Studies were selected based on predefined eligibility criteria, including the use of specific diagnostic criteria for SLE and DLE. After searches in PubMed/MEDLINE, EMBASE, Scopus, Web of Science, LILACS, and LIVIVO databases and gray literature for relevant studies, the selection process was conducted by independent reviewers.

Results: A total of 5,545 articles were identified. After screening, 8 studies met the inclusion criteria. The pooled risk estimate indicated a significantly increased risk of oral cancer in patients with SLE (risk ratio = 2.69; 95% confidence interval, 1.75 to 4.16; I² = 0%; P = .78) compared with the general population. The pooled prevalence of oral cancer in patients with DLE was 10% (95% ci, 0.03 to 0.13; I² = 59%; P = .12).

Conclusions: This review provides evidence supporting an elevated risk for individuals with SLE or DLE developing oral cancer. The findings highlight the importance of monitoring oral mucosa in patients with these conditions.

Publication types

Meta-Analysis
Systematic Review
Review
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cross-Sectional Studies
Humans
Lupus Erythematosus, Discoid* / complications
Lupus Erythematosus, Discoid* / epidemiology
Lupus Erythematosus, Systemic* / complications
Lupus Erythematosus, Systemic* / diagnosis
Lupus Erythematosus, Systemic* / epidemiology
Mouth Neoplasms* / epidemiology
Prevalence