Injection administration of mangosteen, Garcinia mangostana, husk extract enhances physiological and immune-neuroendocrinological regulation of Macrobrachiumrosenbergii

Suwaree Kitikiew; Zheng-Xiang Chieng; Cheng-Ying Li; Hsin-Wei Kuo; Winton Cheng

doi:10.1016/j.fsi.2023.109019

Injection administration of mangosteen, Garcinia mangostana, husk extract enhances physiological and immune-neuroendocrinological regulation of Macrobrachiumrosenbergii

Fish Shellfish Immunol. 2023 Oct:141:109019. doi: 10.1016/j.fsi.2023.109019. Epub 2023 Aug 25.

Authors

Suwaree Kitikiew¹, Zheng-Xiang Chieng², Cheng-Ying Li², Hsin-Wei Kuo³, Winton Cheng⁴

Affiliations

¹ Department of Animal Production Technology and Fisheries, Faculty of Agricultural Technology, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.
² Department of Aquaculture, National Pingtung University of Science and Technology, Pingtung, 91201, Taiwan, ROC.
³ Department of Aquaculture, National Pingtung University of Science and Technology, Pingtung, 91201, Taiwan, ROC; General Research Service Center, National Pingtung University of Science and Technology, Pingtung, 91201, Taiwan, ROC.
⁴ Department of Aquaculture, National Pingtung University of Science and Technology, Pingtung, 91201, Taiwan, ROC. Electronic address: winton@mail.npust.edu.tw.

PMID: 37634755
DOI: 10.1016/j.fsi.2023.109019

Abstract

The study aimed to investigate the effects of injecting mangosteen husk hot-water extracts (MHE) on immune and physiological factors in Macrobrachium rosenbergii. Different doses of MHE (10, 20, and 40 μg prawn^-1) were injected into the prawns, and various immune and physiological parameters were evaluated. The results revealed that higher doses of MHE (20 and 40 μg prawn^-1) led to significant increases in immune parameters, improved phagocytic activity, and clearance efficiency. However, certain parameters, such as phenoloxidase activity per granulocyte, plasma glucose, and lactate levels were decreased after injection. Moreover, prawns injected with MHE and subjected to hypothermal stress exhibited changes in haemolymph dopamine and norepinephrine. Prawns injected with MHE for 7 days showed increased survival rates when challenged with Lactococcus garvieae. The relative survival percentages were 11.8%, 46.6%, and 47.1% for MHE doses of 10, 20, and 40 μg prawn^-1 injection, respectively, indicating enhanced resistance to the pathogen. In conclusion, injecting MHE can act as an immunostimulant and physiological and neuroendocrine regulator for prawns, enhancing their resistance to L. garvieae.

Keywords: Garcinia mangostana; Injection administration; Macrobrachium rosenbergii; Mangosteen husk extract; Physiological and immune neuroendocrine modulators.

MeSH terms

Animals
Dopamine / pharmacology
Garcinia mangostana*
Norepinephrine
Palaemonidae*
Water

Substances

Norepinephrine
Dopamine
Water