The possible anti-seizure properties of Klotho

Nasrin Ranjbar; Mohammadreza Raeisi; Mohammad Barzegar; Amir Ghorbanihaghjo; Siamak Shiva; Shahram Sadeghvand; Sohrab Negargar; Haniyeh Poursistany; Sina Raeisi

doi:10.1016/j.brainres.2023.148555

The possible anti-seizure properties of Klotho

Brain Res. 2023 Dec 1:1820:148555. doi: 10.1016/j.brainres.2023.148555. Epub 2023 Aug 25.

Authors

Nasrin Ranjbar¹, Mohammadreza Raeisi², Mohammad Barzegar³, Amir Ghorbanihaghjo⁴, Siamak Shiva³, Shahram Sadeghvand³, Sohrab Negargar⁵, Haniyeh Poursistany¹, Sina Raeisi⁶

Affiliations

¹ Department of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
² Student Research Committee, Ahvaz Jondishapur University of Medical Sciences, Ahvaz, Iran.
³ Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Biothechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁶ Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Clinical Research Development Unit of Zahra Mardani Azari Children Educational and Treatment Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: raeisis@tbzmed.ac.ir.

PMID: 37634687
DOI: 10.1016/j.brainres.2023.148555

Abstract

Recurrent seizures in epilepsy may lead to progressive neuronal damage, which can diminish health-related quality of life. Evaluation and control of pathological processes in the brain is valuable. It seems imperative that new markers and approaches for seizure alleviation be discovered. Klotho (Kl), an antiaging protein, has protective effects in the brain against neurological disorders. It may also have antiseizure effects by improving creatine transfer to the brain, upregulating excitatory amino acid transporters, and inhibiting insulin/insulin-like growth factor-1 (IGF-1), Wingless (Wnt), transforming growth factor-beta (TGF-β), and retinoic-acid-inducible gene-I (RIG-I)/nuclear translocation of nuclear factor-κB (NF-κB) pathways. Stimulation and activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) and apoptosis signal-regulating kinase 1 (ASK1)/p38 mitogen‑activated protein kinase (MAPK) signaling pathways could also be considered other possible antiseizure mechanisms of Kl. In the present review, the roles of Kl in the central nervous system as well as its possible anti-seizure properties are discussed for the first time.

Keywords: Brain; Epilepsy; Klotho; Seizure; Therapeutic applications.

Publication types

Review