Improving oral squamous cell carcinoma diagnosis and treatment with fluorescence molecular imaging

Jing Fu; Ahmad Alhaskawi; Yanzhao Dong; Feilu Jin; Jing Chen; Xiaodi Zou; Haiying Zhou; Zhenfeng Liu; Sahar Ahmed Abdalbary; Hui Lu

doi:10.1016/j.pdpdt.2023.103760

Improving oral squamous cell carcinoma diagnosis and treatment with fluorescence molecular imaging

Photodiagnosis Photodyn Ther. 2023 Dec:44:103760. doi: 10.1016/j.pdpdt.2023.103760. Epub 2023 Aug 25.

Authors

Jing Fu¹, Ahmad Alhaskawi², Yanzhao Dong², Feilu Jin³, Jing Chen⁴, Xiaodi Zou⁵, Haiying Zhou², Zhenfeng Liu⁶, Sahar Ahmed Abdalbary⁷, Hui Lu⁸

Affiliations

¹ Department of Stomatology, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² Department of Orthopedics, The First Affiliated Hospital, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province, 310003, China.
³ Department of Oral and Maxillofacial Surgery, The 2nd Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China.
⁴ Department of Radiotherapy, Zhejiang cancer hospital, 310022, No.1 Banshan East Road.
⁵ Department of Orthopedics, The First Affiliated Hospital, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province, 310003, China; Department of Zhejiang Chinese Medical University, The Second Affiliated School of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310003, China.
⁶ PET Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, #79 Qingchun Road, Hang-zhou, Zhejiang Province, 310003, PR China.
⁷ Department of Orthopedic Physical Therapy, Faculty of Physical Therapy, Nahda University in Beni Suef, Beni Suef, Egypt.
⁸ Department of Stomatology, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, China; Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Zhejiang University, #866 Yuhangtang Road, Hangzhou, Zhejiang Province, 310058, PR China. Electronic address: huilu@zju.edu.cn.

PMID: 37634605
DOI: 10.1016/j.pdpdt.2023.103760

Abstract

Timely identification and complete removal of oral squamous cell carcinoma (OSCC) through surgery is crucial for effective treatment. However, current diagnostic methods that rely on physical abnormalities are not very informative and practical in clinical settings, leading to the late detection of oral cancer. Furthermore, no dependable intraoperative tools available for assessing surgical margins in real-time. Fluorescence imaging allows the visualization of biological processes occurring in the early stages of cancer, and as a result, small tumors can be detected at an early stage. Fluorescence imaging can effectively aid in assessing excised edges during surgery for OSCC as it possesses high sensitivity and spatial resolution. This review focuses on tongue cancer as a representation of OSCC and delves into various fluorescence techniques that can aid in early diagnosis and surgical guidance. The review also discusses the potential clinical applications of these techniques in the future.

Keywords: Fluorescence molecular imaging; Non-targeted exogenous; Oral squamous cell carcinoma; Precision surgical therapy; Surgical guidance; Targeted fluorescence imaging.

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell* / diagnostic imaging
Carcinoma, Squamous Cell* / pathology
Head and Neck Neoplasms*
Humans
Molecular Imaging
Mouth Neoplasms* / pathology
Optical Imaging / methods
Photochemotherapy* / methods
Photosensitizing Agents
Squamous Cell Carcinoma of Head and Neck

Substances

Photosensitizing Agents