Regulatory role of E3 ubiquitin ligases in normal B lymphopoiesis and B-cell malignancies

Yan Xu; Chengzu Zheng; Muhammad Sameer Ashaq; Qian Zhou; Yuan Li; Chunhua Lu; Baobing Zhao

doi:10.1016/j.lfs.2023.122043

Regulatory role of E3 ubiquitin ligases in normal B lymphopoiesis and B-cell malignancies

Life Sci. 2023 Oct 15:331:122043. doi: 10.1016/j.lfs.2023.122043. Epub 2023 Aug 24.

Authors

Yan Xu¹, Chengzu Zheng¹, Muhammad Sameer Ashaq¹, Qian Zhou¹, Yuan Li¹, Chunhua Lu², Baobing Zhao³

Affiliations

¹ Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Department of Pharmacology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
² Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
³ Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Department of Pharmacology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China. Electronic address: baobingzh@sdu.edu.cn.

PMID: 37633415
DOI: 10.1016/j.lfs.2023.122043

Abstract

E3 ubiquitin ligases play an essential role in protein ubiquitination, which is involved in the regulation of protein degradation, protein-protein interactions and signal transduction. Increasing evidences have shed light on the emerging roles of E3 ubiquitin ligases in B-cell development and related malignances. This comprehensive review summarizes the current understanding of E3 ubiquitin ligases in B-cell development and their contribution to B-cell malignances, which could help explore the molecular mechanism of normal B-cell development and provide potential therapeutic targets of the related diseases.

Keywords: B-cell development; B-cell malignancies; Ubiquitin ligase; Ubiquitination.

Publication types

Review

MeSH terms

Humans
Lymphopoiesis
Neoplasms*
Ubiquitin-Protein Ligases* / metabolism
Ubiquitination
Ubiquitins / metabolism

Substances

Ubiquitin-Protein Ligases
Ubiquitins