Novel Derivatives of Nitrobenzofurazan with Chromogenic and Fluorogenic Properties

Alexandru Bujor; Anamaria Hanganu; Rodica Baratoiu; Elena N Hristea; Madalina Tudose; Victorita Tecuceanu; Augustin M Madalan; Petre Ionita

doi:10.3390/molecules28166146

Novel Derivatives of Nitrobenzofurazan with Chromogenic and Fluorogenic Properties

Molecules. 2023 Aug 20;28(16):6146. doi: 10.3390/molecules28166146.

Authors

Alexandru Bujor¹, Anamaria Hanganu^{1

2}, Rodica Baratoiu³, Elena N Hristea³, Madalina Tudose³, Victorita Tecuceanu², Augustin M Madalan¹, Petre Ionita¹

Affiliations

¹ Department of Inorganic, Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90 Panduri, 050663 Bucharest, Romania.
² Institute of Organic and Supramolecular Chemistry, Spl. Independentei 202B, 060023 Bucharest, Romania.
³ Institute of Physical Chemistry, Spl. Independentei 202, 060023 Bucharest, Romania.

Abstract

Five new derivatives were obtained utilizing 4-chloro-7-nitrobenzofurazan (NBD-chloride) in combination with furfurylamine, adamantylamine, aminohippuric acid, phenylalanine, and dehydroabietylamine. These derivatives were then subjected to a comparative analysis of their physical, chemical, and certain biological properties alongside two analogous and known compounds derived from the glycine and 4-amino-TEMPO free radical.

Keywords: NBD; fluorescence; synthesis.

Grants and funding

Partial funding from CSUD-UB is acknowledged.